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2026

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Asymmetric Total Syntheses of Eliglustat and C2-epi-Eliglustat

Miguel Mellado-Hidalgo, Anna M. Costa, Pedro Romea, Fèlix Urpí, and Gabriel Aullón.

J. Org. Chem. 2026, 91, 3329−3335

Doi: 10.1021/acs.joc.5c03229

Asymmetric Total Syntheses of Eliglustat and C2-epi-Eliglustat

2025

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Direct and asymmetric C–C bond-forming reactions catalyzed by chiral Ni(II) complexes

Eduard Balaguer-Garcia, Javier Ballester, Joan Conejos-Jalencas, Jiawei Gao, Xènia Tarrach, Anna M. Costa, Pedro Romea, and Fèlix Urpí.

Revista de la Societat Catalana de Química 2025, 24, 7−26

Doi: 10.2436/20.2003.01.157

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Direct, Asymmetric, and Stereodivergent Reactions of N‑Azidoacetyl Thioimides with Aromatic Acetals Catalyzed by Chiral Nickel(II) Complexes. An Approach to the Synthesis of syn- and anti-β‑Alkoxy-α-amino Acids

Miguel Mellado-Hidalgo, Joan Conejos-Jalencas, Saúl F. Teloxa, Andrea Suárez-Herrera, Luke McCall, Anna M. Costa, Pedro Romea, Fèlix Urpí, Gabriel Aullón, and Cristina Puigjaner.

J. Org. Chem. 2025, 90, 8519−8530

Doi: 10.1021/acs.joc.5c00390

Direct, Asymmetric, and Stereodivergent Reactions of N‑Azidoacetyl Thioimides with Aromatic Acetals Catalyzed by Chiral Nickel(II) Complexes. An Approach to the Synthesis of syn- and anti-β‑Alkoxy-α-amino Acids
Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

In Search of Radical Transformations from Metal Enolates. Direct Reactions of N‑Acyl-1,3-oxazolidin-2-ones with TEMPO Catalyzed by Copper(II) Acetate

Eduard Balaguer-Garcia, Marina Pérez-Palau, Cristina Bello, Anna Maria Costa, Pedro Romea, and Fèlix Urpí.

J. Org. Chem. 2025, 90, 7332−7339

Doi: 10.1021/acs.joc.5c00457

In Search of Radical Transformations from Metal Enolates. Direct Reactions of N‑Acyl-1,3-oxazolidin-2-ones with TEMPO Catalyzed by Copper(II) Acetate

2024

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Stereocontrolled Aldol-Like Reactions Involving Oxocarbenium Intermediates

Oriol Galeote, Stuart C. D. Kennington, Miguel Mellado-Hidalgo, Anna M. Costa, Pedro Romea, and Fèlix Urpí.

Synlett 2024, 35, 1500–1529

Doi: 10.1055/a-2184-5115

Stereocontrolled Aldol-Like Reactions Involving Oxocarbenium Intermediates
Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Direct, Stereodivergent, and Catalytic Michael Additions of Thioimides to α,β-Unsaturated Aldehydes – Total Synthesis of Tapentadol

Oriol Galeote, Stuart C. D. Kennington, Gabriela Benedito, Lena Fraedrich, Evan Davies-Howe, Anna M. Costa, Pedro Romea, Fèlix Urpí, Gabriel Aullón, Mercè Font-Bardia, and Cristina Puigjaner.

Angew. Chem. Int. Ed. 2024, 63, e202319308

Doi: 10.1002/anie.202319308

Direct, Stereodivergent, and Catalytic Michael Additions of Thioimides to α,β-Unsaturated Aldehydes – Total Synthesis of Tapentadol
Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Diastereoselective Aldol Reactions

Stuart C. D. Kennington, Anna M. Costa, Pedro Romea, and Fèlix Urpí.

Comprehensive Chirality (Second Edition) Volume 1. 2024, 9–51

Doi: 10.1016/B978-0-32-390644-9.00070-6

2023

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Protected syn-Aldol Compounds from Direct, Catalytic, and Enantioselective Reactions of N‑Acyl-1,3-oxazinane-2-thiones with Aromatic Acetals

Miguel Mellado-Hidalgo, Elias A. Romero-Cavagnaro, Sajanthanaa Nageswaran, Sabrina Puddu, Stuart C. D. Kennington, Anna M. Costa, Pedro Romea, Fèlix Urpí, Gabriel Aullón, and Mercè Font-Bardia.

Org. Lett. 2023, 25, 659–664

Doi: 10.1021/acs.orglett.2c04254

Protected syn-Aldol Compounds from Direct, Catalytic, and Enantioselective Reactions of N‑Acyl-1,3-oxazinane-2-thiones with Aromatic Acetals

2022

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Optimized Asymmetric Synthesis of Umuravumbolide

Marina Pérez-Palau, Eduard Balaguer-Garcia, Pedro Romea, and Fèlix Urpí.

ACS Omega 2022, 7, 30835–30840

Doi: 10.1021/acsomega.2c02304

Optimized Asymmetric Synthesis of Umuravumbolide
Direct, Enantioselective, and Nickel(II) Catalyzed Reactions of N-Azidoacetyl Thioimides with Trimethyl Orthoformate: A New Combined Methodology for the Rapid Synthesis of Lacosamide<br /> and Derivatives<br />

Direct and Asymmetric Aldol Reactions of N-Azidoacetyl-1,3-thiazolidine-2-thione Catalyzed by Chiral Nickel(II) Complexes. A New Approach to the Synthesis of β-Hydroxy-α-Amino Acids

Saul F. Teloxa, Miguel Mellado-Hidalgo, Stuart C. D. Kennington, Pedro Romea, Fèlix Urpí, Gabriel Aullón, and Mercè Font-Bardia.

Chem. Eur. J. 2022, 28, e202200671

Doi: 10.1002/chem.202200671

Direct and Asymmetric Aldol Reactions of N-Azidoacetyl-1,3-thiazolidine-2-thione Catalyzed by Chiral Nickel(II) Complexes. A New Approach to the Synthesis of β-Hydroxy-α-Amino Acids

Synthesis of [(R)-DTBM-SEGPHOS]NiCl2 for the Enantioselective Acetal Formation from N Propanoyl-1,3-Thiazinane-2-thione and Trimethyl Orthoformate

Stuart C. D. Kennington, Pedro Romea, and Fèlix Urpí.

Org. Synth. 2022, 99, 1–14

Doi: 10.15227/orgsyn.099.0001

Synthesis of [(R)-DTBM-SEGPHOS]NiCl2 for the Enantioselective Acetal Formation from N Propanoyl-1,3-Thiazinane-2-thione and Trimethyl Orthoformate

2021

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Marina Pérez-Palau, Nil Sanosa, Pedro Romea, Fèlix Urpí, Rosa López, Enrique Gómez-Bengoa, and Mercè Font-Bardia.

Org. Lett. 2021, 23, 8852–8856

Doi: 10.1021/acs.orglett.1c03366

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters
Direct, Enantioselective, and Nickel(II) Catalyzed Reactions of N-Azidoacetyl Thioimides with Trimethyl Orthoformate: A New Combined Methodology for the Rapid Synthesis of Lacosamide<br /> and Derivatives<br />

Synthesis and Acylation of 1,3-Thiazinane-2-thione

Stuart C. D. Kennington, Oriol Galeote, Miguel Mellado-Hidalgo, Pedro Romea, and Fèlix Urpí.

Org. Synth. 2021, 98, 374–390

Doi: 10.15227/orgsyn.098.0374

Synthesis and Acylation of 1,3-Thiazinane-2-thione

Direct and Enantioselective Aldol Reactions Catalyzed by Chiral Nickel(II) Complexes

Stuart C. D. Kennington, Saul F. Teloxa, Miguel Mellado-Hidalgo, Oriol Galeote, Sabrina Puddu, Marina Bellido, Pedro Romea, Fèlix Urpí, Gabriel Aullón, and Mercè Font-Bardia.

Angew. Chem. Int. Ed. 2021, 60, 15307–15312

Doi: 10.1002/anie.202104352

Direct and Enantioselective Aldol Reactions Catalyzed by Chiral Nickel(II) Complexes

2020

Direct, Enantioselective, and Nickel(II) Catalyzed Reactions of N-Azidoacetyl Thioimides with Trimethyl Orthoformate: A New Combined Methodology for the Rapid Synthesis of Lacosamide<br /> and Derivatives<br />

Direct, Enantioselective, and Nickel(II) Catalyzed Reactions of N-Azidoacetyl Thioimides with Trimethyl Orthoformate: A New Combined Methodology for the Rapid Synthesis of Lacosamide and Derivatives

Saul F. Teloxa, Stuart C. D. Kennington, Marc Camats, Pedro Romea, Fèlix Urpí, Gabriel Aullón, and Mercè Font-Bardia.

Chem. Eur. J. 2020, 26, 11540–11548

Doi: 10.1002/chem.202001057

Direct, Enantioselective, and Nickel(II) Catalyzed Reactions of N-Azidoacetyl Thioimides with Trimethyl Orthoformate: A New Combined Methodology for the Rapid Synthesis of Lacosamide and derivates

Stereoselective Decarboxylative Alkylation of Titanium(IV) Enolates with Diacyl Peroxides

Alejandro Gómez-Palomino, Marina Pérez-Palau, Pedro Romea, Fèlix Urpí, Marc Del Olmo, Timo Hesse, Sonja Fleckenstein, Enrique Gómez-Bengoa, Lia Sotorríos, and Mercè Font-Bardia.

Org. Lett. 2020, 22, 199−203

Doi: 10.1021/acs.orglett.9b04148

Stereoselective Decarboxylative Alkylation of Titanium(IV) Enolates with Diacyl Peroxides

2019

General and stereoselective aminoxylation of biradical titanium(IV) enolates with TEMPO: a detailed study on the effect of the chiral auxiliary

Direct anti Glycolate Aldol Reaction of Protected Chiral N-Hydroxyacetyl Thiazolidinethiones with Acetals Catalyzed by a Nickel(II) Complex

Juan Manuel Romo, Pedro Romea, and Fèlix Urpí.

Eur. J. Org. Chem. 2019, 6296–6305

Doi: 10.1002/ejoc.201901097

Direct anti Glycolate Aldol Reaction of Protected Chiral N-Hydroxyacetyl Thiazolidinethiones with Acetals Catalyzed by a Nickel(II) Complex
General and stereoselective aminoxylation of biradical titanium(IV) enolates with TEMPO: a detailed study on the effect of the chiral auxiliary

Stereoselective Synthesis of Protected Peptides Containing an anti  β-Hydroxy Tyrosine

Javier Fernández-Valparis, Pedro Romea, and Fèlix Urpí.

Eur. J. Org. Chem. 2019, 2745–2752

Doi: 10.1002/ejoc.201900301

Stereoselective Synthesis of Protected Peptides Containing an anti  β-Hydroxy Tyrosine

Direct and Asymmetric Nickel(II)-Catalyzed Construction of Carbon−Carbon Bonds from N‑Acyl Thiazinanethiones

Stuart C. D. Kennington, Adam J. Taylor, Pedro Romea, Fèlix Urpí, Gabriel Aullón, Mercè Font-Bardia, Laura Ferré, and Jesus Rodrigalvarez.

Org. Lett. 2019, 21, 305−309

Doi: 10.1021/acs.orglett.8b03757

Direct and Asymmetric Nickel(II)-Catalyzed Construction of Carbon−Carbon Bonds from N‑Acyl Thiazinanethiones

2018

General and stereoselective aminoxylation of biradical titanium(IV) enolates with TEMPO: a detailed study on the effect of the chiral auxiliary

General and stereoselective aminoxylation of biradical titanium(IV) enolates with TEMPO: a detailed study on the effect of the chiral auxiliary

Stuart C. D. Kennington, Alejandro Gómez-Palomino, Ernest Salomó, Pedro Romea, Fèlix Urpí, and Mercè Font-Bardia.

Org. Biomol. Chem. 2018, 16, 4807–4815

Doi: 10.1039/c8ob01074a

General and stereoselective aminoxylation of biradical titanium(IV) enolates with TEMPO: a detailed study on the effect of the chiral auxiliary

Stereoselective Oxidation of Titanium(IV) Enolates with Oxygen

Alejandro Gómez-Palomino, Pedro Romea, and Fèlix Urpí.

Synthesis 2018, 50, 2721–2726

Doi: 10.1055/s-0037-1609966

Stereoselective Oxidation of Titanium(IV) Enolates with Oxygen

2017

Stereoselective and Catalytic Synthesis of anti-β-Alkoxy-α-azido Carboxylic Derivatives

Javier Fernández-Valparis, Pedro Romea, Fèlix Urpí, and Mercè Font-Bardia.

Org. Lett. 2017, 19, 6400–6403

Doi: 10.1021/acs.orglett.7b03255

Stereoselective and Catalytic Synthesis of anti-β-Alkoxy-α-azido Carboxylic Derivatives

Substrate-Controlled Michael Additions of Titanium Enolates from Chiral α-Benzyloxy Ketones to Conjugated Nitroalkenes

Alejandro Gómez-Palomino, Adrián Barrio, Pedro García-Lorente, Pedro Romea, Fèlix Urpí, and Mercè Font-Bardia.

Eur. J. Org. Chem. 2017, 5776–5784

Doi: 10.1002/ejoc.201701055

Substrate-Controlled Michael Additions of Titanium Enolates from Chiral α-Benzyloxy Ketones to Conjugated Nitroalkenes

Experimental and Computational Evidence of the Biradical Structure and Reactivity of Titanium(IV) Enolates

Carlos Heras, Alejandro Gómez-Palomino, Pedro Romea, Fèlix Urpí, Josep Maria Bofill, and Iberio de P. R. Moreira.

J. Org. Chem. 2017, 82, 8909–8916

Doi: 10.1021/acs.joc.7b01174

Experimental and Computational Evidence of the Biradical Structure and Reactivity of Titanium(IV) Enolates

Diastereoselective and Catalytic α‑Alkylation of Chiral N‑Acyl Thiazolidinethiones with Stable Carbocationic Salts

Stuart C. D. Kennington, Mònica Ferré, Juan Manuel Romo, Pedro Romea, Fèlix Urpí, and Mercè Font-Bardia.

J. Org. Chem. 2017, 82, 6426–6433

Doi: 10.1021/acs.joc.7b00657

Diastereoselective and Catalytic α‑Alkylation of Chiral N‑Acyl Thiazolidinethiones with Stable Carbocationic Salts

Total synthesis of (+)-herboxidiene/GEX 1A

Alejandro Gómez-Palomino, Miquel Pellicena, Katrina Krämer, Pedro Romea, Fèlix Urpí, Gabriel Aullón, and José M. Padrón.

Org. Biomol. Chem. 2017, 15, 1842–1862

Doi: 10.1039/c7ob00072c

Total synthesis of (+)-herboxidiene/GEX 1A

Substrate-Controlled Aldol Reactions from Chiral α-Hydroxy Ketones

Gabriel Aullón, Pedro Romea, and Fèlix Urpí.

Synthesis 2017, 49, 484–503

Doi: 10.1055/s-0036-1588888

Substrate-Controlled Aldol Reactions from Chiral α-Hydroxy Ketones

2016

Stereoselective Synthesis of the C9−C19 Fragment of Peloruside A

Stuart C. D. Kennington, Juan M. Romo, Pedro Romea, and Fèlix Urpí.

Org. Lett. 2016, 18, 3018–3021

Doi: 10.1021/acs.orglett.6b01428

Stereoselective Synthesis of the C9−C19 Fragment of Peloruside A

Studies towards the synthesis of tedanolide C. Construction of the C13-epi C1–C15 fragment

Joana Zambrana, Pedro Romea, and Fèlix Urpí.

Org. Biomol. Chem. 2016, 14, 5219–5223

Doi: 10.1039/c6ob00896h

Studies towards the synthesis of tedanolide C. Construction of the C13-epi C1–C15 fragment

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